Johns Hopkins University

For the thirty-fifth year in a row, Johns Hopkins spent more on research than any other university in the country — a total of $2.2 billion dollars worth of medical, engineering, and science research, $1.89 billion of it supported by federal funds from the NIH, Department of Defense, NASA, and other organizations.

The University of Michigan came in a distant second, with $1.27 billion.

Recent declines in federal science funding have meant that Johns Hopkins (and other universities) are having to find new ways to make up the difference. While total research spending is rising, the percent that comes from government sources has declined 1.7% over the past year.